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Type 2 diabetes is a risk factor for developing dementia, and people with alzheimer’s disease display signs of insulin resistance in the brain. Epub 2025 apr 23 pubmed. The discovery and development of liraglutide and semaglutide. J parkinsons dis. Kenzheshova a, moldasheva a, aljofan m. 2024 may 14;331 (18):1519-1521. Zhang l, zhang l, li l, hölscher c. · semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xtg mouse model of alzheimers disease via the glp-1r/sirt1/glut4 pathway. Semaglutide is neuroprotective and reduces α-synuclein levels in the chronic mptp mouse model of parkinsons disease. Ozempic tm is a once-per-week injection formulation, while rybelsus tm is is a daily pill. Epub 2019 apr 12 pubmed. Novel lc-ms/ms analysis of the glp-1 analog semaglutide with its application to pharmacokinetics and brain … Front endocrinol (lausanne). Knudsen lb, lau j. Lee ts, park ej, choi m, oh hs, an y, kim t, kim th, shin bs, shin s. · in diet-induced obesity in these mice, nt-0796 caused weight loss as potently as did the glp1 inhibitor semaglutide, and improved markers of cardiovascular risk (thornton et … Glp-1 is a hormone that is produced in the gut and activates receptors in the gut, liver, and pancreas to … These findings have spurred testing of multiple …