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Aging is an important risk factor for adverse events in elderly patients with atrial fibrillation (af) and complicates the management of anticoagulation. · despite the limitations of this ipdma, it supports the evidence for early initiation of oral anticoagulation in atrial fibrillation-associated acute ischaemic stroke, especially in … · patients with acute ischemic stroke (ais) in the setting of atrial fibrillation (afib) will need to start/resume anticoagulation (ac) as it is the mainstay for secondary stroke prevention. · atrial fibrillation (af) accounts for about 20–30% of ischaemic strokes. The efficacy of anticoagulation for primary prevention of stroke … · the optimal timing of oral anticoagulation for prevention of early ischaemic stroke recurrence in people with acute ischaemic stroke and atrial fibrillation remains uncertain. 10. 1016/s0140-6736 (24)02259-1. Online ahead of print. · we aimed to estimate the effects of starting a direct oral anticoagulant (doac) early (≤4 days) versus later (≥5 days) after onset of ischaemic stroke. This meta-analysis of 11 studies (two rcts and nine cohort studies) investigated the trend of optimal timing for initiating direct oral anticoagulants (doacs) for secondary stroke prevention … Underuse of oral anticoagulants (oacs) … · we summarize the major advances in stroke prevention for patients with atrial fibrillation during the past 30 years and focus on novel diagnostic and treatment approaches … Optimal anticoagulation timing after ischaemic stroke in patients with atrial fibrillationlancet. · in the absence of high-quality evidence to support timing of doacs after acute ischemic stroke in atrial fibrillation the optimas trial hopes to establish safety and efficacy of … 2024 oct 23:s0140-6736 (24)02259-1. Deciding when to initiate oral … · the optimal timing of anticoagulation after acute ischaemic stroke (optimas) trial aimed to establish the safety and efficacy of early anticoagulation with a doac in a broad …despite the limitations of this ipdma, it supports the evidence for early initiation of oral anticoagulation in atrial fibrillation-associated acute ischa… About 13-26% of all acute ischaemic strokes are related to non-valvular atrial fibrillation, the most common cardiac arrhythmia globally. Nonvalvular atrial fibrillation (nvaf) is frequently seen in elderly people and has become a main cause of cardioembolic stroke. Direct oral anticoagulants (doacs) are very effective for long-term secondary prevention of ischaemic … Early oac-initiation in acute ischemic stroke patients with non-valvular atrial fibrillation appears to have better efficacy and a similar safety profile compared … Optimal timing of oral anticoagulation (toac) in acute ischemic stroke (ais) in patients with atrial fibrillation (af) is unknown. The risk of recurrent ischemic events …