· as a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (stat3) is central in regulating the anti-tumor … Stat3 has been shown to play a pro-cancer role … · signal transducer and activator of transcription 3 (stat3) is a key element in multiple signaling pathways. We would like to show you a description here but the site won’t allow us. · signal transducer and activator of transcription 3 (stat3) is a transcriptional factor involved in almost all cancer hallmark features including tumor proliferation, metastasis, … In this review, the current knowledge of stat3 in pancreatic cancer has been summarized, particularly relating to stat3 activation in cancer cells, cells of the tme, and the state of … · overall, we found that stat3 significantly predicted cancer prognosis, drug resistance, and immunotherapy, providing a rationale for further experimental studies. 5, 6 although kras, cdkn2a, smad4, and tp53 are known as driver genes in pdac, these genes … · pancreatic cancer (pc) remains highly malignant and has a very miserable prognosis with a 5-year survival rate of about 11% [1] partly due to its poor early detection rate. · though only a few trials have shown the efficacy in a clinical setting, the stat3 pathway remains a promising drug target for future treatment of pancreatic ductal … · this is the first report of evaluating a chemical inhibitor of stat3 on pancreatic cancer with promising outcomes that sheds light on our understanding of the pathophysiology … · stat3 is hyperactive in cancer cells as a result of upstream stat3 mutations or enhanced cytokine production in the tumour environment. · we report here that this jak1/stat3/integrin β3 axis accelerates pdac initiation and progression and demonstrate stat3 as necessary for stress- and inflammation-induced … · the genetic background of pancreatic cancer is intricate and complicated. The stat3 signalling pathway … Preclinical studies strongly suggest significant efficacy of drugs targeting gp130/jak/stat3 in the treatment of pancreatic ductal adenocarcinoma and that these molecules are effective … Despite the advances in the treatment of pancreatic cancer in the past decade, the prognosis for patients with pancreatic cancer remains poor. Stat3 is prevalent and active in a variety of human cancers.
The Stat3 Pathway The Underrated Factor In Pancreatic Cancer Prognosis
· as a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (stat3) is central in regulating the anti-tumor...
